Epigenetics: Challenging the Central Dogma and National Selection
The central dogma of molecular biology, proposed by Francis Crick in 1958, describes the unidirectional flow of genetic information from DNA to RNA to protein. This concept has been a cornerstone of molecular biology for decades, providing a framework for understanding how genetic information is expressed and passed on. However, the emergence of epigenetics has challenged the simplicity of the central dogma, revealing a more complex and nuanced picture of gene regulation. Epigenetics refers to heritable changes in gene expression that occur without alterations to the underlying DNA sequence. These changes are brought about by modifications to the structure of DNA or associated proteins, influencing how genes are accessed and transcribed. Epigenetic mechanisms can be influenced by environmental factors, lifestyle choices, and developmental experiences, adding another layer of complexity to the regulation of gene expression. Key epigenetic mechanisms that ch...