Lamarck's Vitamin D cures Darwin's Rickets

Epigenetics is the study of how changes in gene expression can be inherited without changes in the DNA sequence unlike NeoDarwinism.


These changes can be caused by environmental factors, such as exposure to sunlight.

When the skin is exposed to sunlight, it produces vitamin D. However, over time, the skin can become less responsive to sunlight, and this can lead to vitamin D deficiency. This is because the DNA in the skin can become methylated, which silences the genes that are involved in vitamin D production.


Epigenetics has a significant impact on vitamin D levels. A systematic review published in 2023 (bottom)  examined the evidence for the effect of epigenetics on vitamin D levels. It's not a matter of having a gene rather how it's turned on and off by epigenetics. This differs from the NeoDarwinism gene centric view.


The review included nine studies that investigated the association between epigenetic changes and vitamin D levels. The studies looked at methylation of genes involved in vitamin D metabolism, such as CYP2R1, CYP27B1, and CYP24A1. They also looked at histone modifications, which are changes to the structure of histone proteins that can affect gene expression.

The review found that epigenetic changes were associated with vitamin D levels in a number of ways. For example, methylation of the CYP2R1 gene was associated with lower vitamin D levels, while methylation of the CYP24A1 gene was associated with higher vitamin D levels. Histone modifications were also associated with vitamin D levels, but the findings were less consistent.

The review concluded that epigenetic changes played a greater role than the NeoDarwinian gene centric view. The genes only accounted for 20% of the change where epigenetics did the rest.

There are a number of studies that have shown a link between epigenetics and vitamin D levels. One study, published in the journal Nature, found that people with certain epigenetic changes were more likely to have low vitamin D levels, even if they lived in a sunny region. .

Another study, published in the journal Epigenomics, found that epigenetic changes in the VDR gene, which is involved in vitamin D metabolism, were associated with lower vitamin D levels in people who lived in northern Europe. 

Intrinsically disordered proteins (IDPs) with intrinsically disordered regions (IDRs) are resistant to Darwin's mutations over billions of years because they do not have a fixed structure. This means that they are less likely to be disrupted by mutations, which can often lead to changes in protein function.


IDPs can also be transferred between organisms via the horizontal gene transfer (HGT) of transposable elements (TEs). TEs are mobile genetic elements that can insert themselves into the genomes of other organisms. When a TE inserts into an IDP, it can create a new IDR in the host protein. This new IDR can then be inherited by the host's offspring, allowing the IDP to be transferred to new populations.


The combination of resistance to mutations and the ability to be transferred via HGT means that IDPs can play an important role in Lamarckian evolution. They can help to create new proteins with new functions, and they can also help to spread existing proteins to new populations.

The vitamin D receptor (VDR) is an intrinsically disordered protein (IDP), which means that its structure is not fixed but instead can change depending on its environment. This makes it difficult for mutations to disrupt the function of the VDR, as even if a mutation changes several amino acids the overall structure of the protein may still be able to function properly.

The phylogenetic evidence suggests that vitamin D is billions of years old. In a 2017 study published in the journal Nature, researchers analyzed the genomes of over 1,000 different species of animals, including fish, amphibians, reptiles, birds, and mammals. They found that all of these species have a gene that codes for vitamin D.

The researchers also found that the vitamin D gene has been conserved over time. This means that the basic structure of the gene has not changed much since it first appeared. 

No Darwinian gradualism for billions of year's. 

This suggests that vitamin D is an essential molecule for all animals.

The finding that vitamin D is billions of years old has implications for our understanding of human health. It suggests that vitamin D is not just a modern nutrient, but that it has been essential for human health even before we came on the scene. 

This represents a total fail for NeoDarwinism. It can only act on the here and now. To suggest it is only recently acting on humans fails natural selection. It could not have fashioned  a gene  billions of years ago in anticipation of our needs in the last 100,000 years since Mit Eve and Y Chromosome Adam arose.

Effect of epigenetics on vitamin D levels: a systematic review until December 2020

Nature 6/23


The epigenetic modification of the vitamin D-related genes could explain the vitamin D levels variation among populations. Large-scale clinical trials in various ethnicities are suggested to find the effect of epigenetics on vitamin D response variation.

Vitamin D affects the epigenome on multiple levels and has a substantial role in the epigenetic regulation of genes

epigenetic modulation of vitamin D-related genes could be the reason for vitamin D level variance among the population.

According to the studies, the methylation status of CYP2R1, CYP27B1, CYP24A1, and VDR genes is responsible for nearly 18% of the vitamin D level variance

Epigenetic modification plays a crucial role in regulating vitamin D levels and vitamin D response variation. Epigenetic changes could be considered to recommend the appropriate dosage of vitamin D supplementation

According to the discrepancy in the method of studies, different populations, and methods of vitamin D level and methylation status assessment, reviewed studies showed diversity in the correlated CpG sites of each gene and their association with vitamin D level.

It is suggested that genetic variation can only predict 20% of the variation in vitamin D response indices, while the remaining could be due to epigenetic variations


https://archpublichealth.biomedcentral.com/articles/10.1186/s13690-023-01122-2


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