Lamarckian Intrinsically Disoreded Proteins can resist evolution for over a billion years


Lamarckism, the theory that acquired characteristics can be inherited, is considered to be outside of NeoDarwinian evolution, which is based on the theory of natural selection. However, there is now strong evidence that Lamarckian evolution may play a role in evolution. One way is in the function of Intrinsically disordered proteins (IDPs).

IDPs are proteins that do not have a fixed three-dimensional structure. Instead, they are flexible and can adopt different conformations depending on their environment. NeoDarwinian theory was developed on structural proteins. Mutations could change them for natural selection to act. Phylogenetic's has identified IDPs with no change in function over a billion years. This in spite of having more mutations. Per NeoDarwinism more mutations should mean more evolution yet IDPs violates this central axiom of evolutionary theory. Due to IDPs flexible shape they absorb NeoDarwinian mutations with no change in function. As this can persist over a billion years this violates NeoDarwinian gradualistic mutations over time. No evolution for over a billion years.

This makes IDPs ideal for a variety of functions outside of NeoDarwinian structural proteins including:

  • Signal transduction: IDPs can act as signal transducers, carrying information from one part of the cell to another.

  • Regulation of gene expression: IDPs can bind to DNA and RNA, regulating the expression of genes.

  • Enzyme catalysis: IDPs can act as enzymes, catalyzing chemical reactions.

  • Protein-protein interactions: IDPs can interact with other proteins, forming complexes that carry out specific functions.

Lamarckian evolution is the idea that acquired traits can be inherited by offspring. This means that changes that an organism makes to its own body during its lifetime can be passed on to its descendants.

IDPs may play a role in Lamarckian evolution. For example, one study showed that IDPs can be modified by environmental factors, such as stress or exposure to toxins. These modifications can then be inherited by offspring.

Another study showed that IDPs can be involved in the process of epigenetics, which is the study of changes in gene expression that are not caused by changes in the DNA sequence. Epigenetic changes can also be inherited by offspring.

Therefore, IDPs can play a role in Lamarckian evolution by allowing acquired traits to be inherited.

Here are some specific ways that IDPs are Lamarckian:

  • IDPs can be modified by environmental factors, such as stress or exposure to toxins. These modifications can then be inherited by offspring.

  • IDPs can be involved in the process of epigenetics, which is the study of changes in gene expression that are not caused by changes in the DNA sequence. Epigenetic changes can also be inherited by offspring.

  • IDPs can be involved in the formation of new cell types. This could allow an organism to adapt to a new environment by acquiring new traits.

  • IDPs can play a role in the repair of damaged DNA. This could help an organism to survive in a harsh environment.

Overall, IDPs are a complex and fascinating group of proteins that play a role in Lamarckian evolution. More research is needed to fully understand their role in evolution, but they are a promising area of research for understanding how organisms adapt to their environment.

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