Epigenetic's "Alternative Splicing" defeats Darwin's "Single Gene Single Phynotype"



The article "Differential exon usage of developmental genes is associated with deregulated epigenetic marks" shows how exomes can be alternatively sliced to form different proteins outside of NeoDarwinism:

  • Background: Alternative exon usage (AEU) is a common phenomenon in mammalian genomes, where different combinations of exons are used to produce different protein isoforms. AEU can have a significant impact on the function of a protein, as different isoforms can have different structures, activities, and interactions.

  • Findings: The authors of this study analyzed data from the Human Epigenome Atlas to investigate the relationship between AEU and epigenetic marks in developmental genes. They found that genes with differential exon usage in different developmental stages were more likely to have deregulated epigenetic marks in the flanking regions of the exons. These epigenetic marks included histone modifications, DNA methylation, and nucleosome occupancy.

  • Significance: These findings suggest that AEU and epigenetic marks are closely linked, and that they may play a role in regulating the development of different tissues and organs. The authors suggest that further research is needed to investigate the mechanisms by which AEU and epigenetic marks interact to control gene expression during development.

Here are some of the key points from the article:

  • AEU is a common phenomenon in mammalian genomes, and it can have a significant impact on the function of a protein.

  • Genes with differential exon usage in different developmental stages are more likely to have deregulated epigenetic marks in the flanking regions of the exons.

  • Epigenetic marks, such as histone modifications, DNA methylation, and nucleosome occupancy, can play a role in regulating AEU.

  • Further research is needed to investigate the mechanisms by which AEU and epigenetic marks interact to control gene expression during development.


The single gene single phenotype model of NeoDarwinism is wrong due to alternative splicing and epigenetics.

  • Alternative splicing is a process in which a single gene can be spliced together in different ways to produce different proteins. This means that a single gene can have multiple phenotypes, depending on how it is spliced.

  • Epigenetics is the study of how environmental factors can change gene expression without changing the DNA sequence. This means that the same gene can have different phenotypes depending on the environment in which it is expressed.

Both alternative splicing and epigenetics can play a role in evolution. For example, if a epimutation in a gene leads to a new splicing pattern, this could produce a new protein with a new phenotype. Similarly, if an environmental factor changes the expression of a gene, this could also produce a new phenotype.

The single gene single phenotype model of NeoDarwinism was based on the idea that the genotype (the genetic makeup of an organism) is directly responsible for the phenotype (the observable characteristics of an organism). However, we now know that the genotype is not the only factor that determines the phenotype. Alternative splicing and epigenetics can also play a role, which means that the relationship between genotype and phenotype is more complex than previously thought.

This has important implications for our understanding of evolution. It means that evolution can be driven by changes in gene expression as well as by changes in the DNA sequence. It also means that the environment can play a role in evolution, by influencing gene expression.




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